Eclipse Phase - CC Licensed Transhumanist/Conspiracy/Horror
is a new RPG I stumbled across. The PDF of the rule book is out, and it's been released under a , so it's legal and easy to find the PDF to check it out to see if you like it.
The setting is a mashup of Vernor Vinge, Ricahrd Morgan, Warren Ellis, David Brin, Alastair Reynolds, Ken Macleod, Charles Stross, Peter Watts (not enough of him I think. The aliens are too human. Assuming they're actually ETs and not sock puppets), etc. Not many women authors.
War, possibly against self-improving AIs, devastated Earth. Transhumans and posthumans survive in orbital habitats, converted asteroids, Lunar and Martian colonies, and further out in the Kuiper belt. Baseline humans are almost extinct. The various factions and clades are concerned that the self-improving AIs might return. There's been contact with entities claiming to be star faring aliens. There are wormholes, presumably constructed by the self improving AIs blamed for the holocaust on Earth, that go elsewhere.
It's a percentile system with a point buy character generation system. PCs can be baseline humans, modified humans, cyborgs, AI, uplifted cephalopods or gorillas, robots, etc.
I'm not sure I like the system, but I love the setting (with some reservations).